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>
> "Peter Bowditch" <myfirstname@ratbags.com> wrote in message
> news:ifkc849c5b0ghcd1c67ckpdve7sdc51gke@4ax.com...
>
>
> Prescription is prescription because someone has proven dangers. PROVE
> otherwise. Prescription is controlled. Why controlled? DUUUHHH
> OTC is no guarantee of safety. BTW, Tylenol in excess of 400 unnits per
> day will cause liver failure in the average person

> AND Tylenol is safer than aspirin.

> Nattokinase (non prescription) is safer and more effective than aspirin
> (non prescription) or Plavix (prescription) (For blood thinning.)
> Aspirin was popular before prescription was even a term.
>
> It doesn't make one bit of difference what YOU take to change the
> definition of a word.
> Please tell us why YOU (no Doctor) think that certain products may be sold
> ONLY under prescription.

>
>
> BTW Why is metformin given under controlled conditions ( prescription)
>
> In many people a MAJOR renal problem.
> Glyburide
> In a single-dose interaction study in type 2 diabetes patients,
> coadministration of metformin and glyburide did not result in any changes
> in either metformin pharmacokinetics or pharmacodynamics. Decreases in
> glyburide AUC and Cmax were observed, but were highly variable. The
> single-dose nature of this study and the lack of correlation between
> glyburide blood levels and pharmacodynamic effects, makes the clinical
> significance of this interaction uncertain (see DOSAGE AND ADMINISTRATION:
> Concomitant GLUCOPHAGE or GLUCOPHAGE XR and Oral Sulfonylurea Therapy in
> Adult Patients).
>
> Furosemide
> A single-dose, metformin-furosemide drug interaction study in healthy
> subjects demonstrated that pharmacokinetic parameters of both compounds
> were affected by coadministration.
>
> Furosemide increased the metformin plasma and blood Cmax by 22% and blood
> AUC by 15%, without any significant change in metformin renal clearance.
> When administered with metformin, the Cmax and AUC of furosemide were 31%
> and 12% smaller, respectively, than when administered alone, and the
> terminal half-life was decreased by 32%, without any significant change in
> furosemide renal clearance. No information is available about the
> interaction of metformin and furosemide when coadministered chronically.
>
> Nifedipine
> A single-dose, metformin-nifedipine drug interaction study in normal
> healthy volunteers demonstrated that coadministration of nifedipine
> increased plasma metformin Cmax and AUC by 20% and 9%, respectively, and
> increased the amount excreted in the urine. Tmax and half-life were
> unaffected. Nifedipine appears to enhance the absorption of metformin.
> Metformin had minimal effects on nifedipine.
>
> Cationic drugs
> Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide,
> quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin)
> that are eliminated by renal tubular secretion theoretically have the
> potential for interaction with metformin by competing for common renal
> tubular transport systems. Such interaction between metformin and oral
> cimetidine has been observed in normal healthy volunteers in both single-
> and multiple-dose, metformin-cimetidine drug interaction studies, with a
> 60% increase in peak metformin plasma and whole blood concentrations and a
> 40% increase in plasma and whole blood metformin AUC. There was no change
> in elimination half-life in the single-dose study. Metformin had no effect
> on cimetidine pharmacokinetics. Although such interactions remain
> theoretical (except for cimetidine), careful patient monitoring and dose
> adjustment of GLUCOPHAGE or GLUCOPHAGE XR and/or the interfering drug is
> recommended in patients who are taking cationic medications that are
> excreted via the proximal renal tubular secretory system.
>
> Other
> Certain drugs tend to produce hyperglycemia and may lead to loss of
> glycemic control. These drugs include the thiazides and other diuretics,
> corticosteroids, phenothiazines, thyroid products, estrogens, oral
> contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium
> channel blocking drugs, and isoniazid. When such drugs are administered to
> a patient receiving GLUCOPHAGE or GLUCOPHAGE XR, the patient should be
> closely observed for loss of blood glucose control. When such drugs are
> withdrawn from a patient receiving GLUCOPHAGE or GLUCOPHAGE XR, the
> patient should be observed closely for hypoglycemia.
>
> In healthy volunteers, the pharmacokinetics of metformin and propranolol,
> and metformin and ibuprofen were not affected when coadministered in
> single-dose interaction studies.
>
> Metformin is negligibly bound to plasma proteins and is, therefore, less
> likely to interact with highly protein-bound drugs such as salicylates,
> sulfonamides, chloramphenicol, and probenecid, as compared to the
> sulfonylureas, which are extensively bound to serum proteins.
>
>